I INFECTION / INFLAMMANATION CONTROL

Chronic wounds are at increased risk of microbial colonization. Not only due to the amount of time the wound is open, but also due to factors such as hypoxia, history of underlying diseases, poor blood flow, among others.

The inflammatory phase in an acute wound is part of the natural trauma response process by releasing cytokines and growth factors, leads to vasodilation and increased blood flow to the affected area. However, in a chronic wound, a continued and prolonged inflammatory response eventually contributes to bacterial proliferation and tissue compromise.

Prevention and local treatment of wound bed infection can be accomplished by preparing the wound bed, debridement of devitalized tissue, cleaning, and the use of antimicrobials, among others.